Endocrine Abstracts

IntroductionMetformin and vildagliptin are the medications amongst first-line treatment options in type 2 diabetes patients. Few recent studies have explained positive pleotropic effects of metformin therapy by telomerase activation and telomeres length in leukocytes preservation. Knowing the primary role of insulin-signalling pathway in insulin resistance development and physiology of ageing, it is possible to suggest, that one of the protective mechani...

It is known that glucose disturbances contribute to vascular ageing. The length of telomere (TL) and telomerase activity (TA) are considered as biomarkers of cellular ageing. It is crucial to determine the role of telomere biology in different vessels changes in diabetic patients. The aim of our study was to determine the role of telomere biology in vascular ageing in patients with T2DM.Results: All patients were divided into two groups by the median of ...